Which food additives have adverse effects on special populations

The only food additive in National food standard that clearly indicates that it may affect a particular group of people is the sweetener aspartame. The chemical name of aspartame is aspartic acid phenylalanine methyl ester, which is synthesized from aspartic acid and phenylalanine. Phenylalanine (PA) is one of the essential amino acids in human body (Malaysia food flavour wholesale) . The daily intake of normal people is 200mg / 500mg. Among them, 1ppm is used to synthesize protein, and 2pm / 3 is converted to tyrosine through phenylalanine hydroxylase (PAH) in hepatocytes to synthesize thyroxine, epinephrine and melanin.

Phenylpyruvate aciduria ((PKU)) is an inherited disorder of phenylalanine metabolism caused by the deficiency or decreased activity of phenylalanine hydroxylase (PAH) in the liver. It belongs to the enzyme defect in the metabolic pathway of phenylalanine, which results in the conversion of phenylalanine with food intake to tyrosine, resulting in the accumulation of phenylalanine and its ketoacid and its excretion from urine.

It is common in hereditary amino acid metabolism deficiency diseases, which is autosomal recessive inheritance. The incidence varies with race (Malaysia food Ingredient supplier) , about 14000 in the United States, 60000 in Japan and 16500 in China. The main clinical features were mental retardation, neurological symptoms, eczema, skin scratching, depigmentation and mouse odor. If early diagnosis and early treatment, the above clinical manifestations can not occur mental retardation, EEG abnormalities can also be recovered.

Therefore, the National food standard stipulates that foods with aspartame should be labeled "aspartame (containing phenylalanine) (Malaysia food flavour supplier)."

In addition, excessive sulfur dioxide can cause chest discomfort and have a strong irritating effect on respiratory mucosa (Malaysia food flavour supplier) . Therefore, sulfur, sulfur dioxide, sulfite and other sulfur food additives are prohibited in infant food, and there are strict maximum usage and residue regulations in foods that can be added to avoid harm to human health.